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Test Data
Test Data
EPTLIN
Gabapentin 300mg + Nortriptyline 10mg
Gabapentin in Neuropathic Pain Disorders
  • FDA approved for postherpetic neuralgia
  • Anticonvulsant: uncertain mechanism.
  • Limited intestinal absorption
  • Usually well tolerated serious adverse effects rare-dizziness and sedation can occur.
  • No significant drug interactions.
  • Peak time: 2 to 3 hours; elemination half-life: 5 to 7 hours.
  • Usual dosage range for neuropathic pain up to 3,600 mg/d(tid-qid)*
Antidepressants in Neuropathic Pain Disorders*
  • Multiple mechanisms of action
  • Randomized controlled trials and meta-analyses demonstrate benefit of tricyclic antidepressants(especally ampitripyline, nortriptyline, desipramine) for postherpetic neuralgia and diabetic neuropathy.
  • Selective serotonin reuptake inhibitors: inconsistent in diabetic neuropathy.
  • Onset of analgesia variable - analgesic effects independent of antidepressants activity.
  • Improvements in insomnia, anxiety, depression.
  • Desipramin and nortriptyline have fewer adverse effects.

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